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Item number: TGM-T3451-100mg

Description: JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). Target: GluR. Smiles: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1. References: Cid JM, et al. Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a...

Application:	Positive allosteric mGlu2 receptor modulator
CAS	1254977-87-1
MW:	400.44 D

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JNJ-42153605

Item number: Cay21984-1

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2, EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50...

Keywords:	3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
Application:	Positive allosteric mGlu2 receptor modulator
CAS	1254977-87-1
MW:	400.4 D

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