BPR0912 is a cannabinoid 1 (CB1) receptor inverse agonist (IC50 = 8.5 nM for the human receptor). It is selective for CB1 over CB2 receptors (IC50 = 604.9 nM for the human receptor). In vivo, BPR0912 (10 mg/kg per day) inhibits diet-induced increases in body weight, epididymal and inguinal fat pad mass, and serum...