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LGK974
Item number: TGM-T2618-100mg
Description: LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck. Target: Porcupine. Smiles:...
| Keywords: | LGK-974, LGK 974, NVP-LGK974, WNT974 |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.44 D |
From 42.00€
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LGK974
Item number: Cay14072-5
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4...
| Keywords: | PORCN Inhibitor IV, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.4 D |
From 52.00€
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LGK-974
Item number: LKT-L2540.1
LGK-974 inhibits PORCN, suppressing Wnt signaling. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. LGK-974 inhibits proliferation and induces differentiation of pancreatic adenocarcinoma xenografts, it also shows efficacy in suppressing tumor growth in animal models...
| Keywords: | LGK974 |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.44 D |
From 109.00€
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