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Balipodect
Item number: TGM-T1745-100mg
Description: Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM), Its selectivity is >15000-fold over other PDEs. Target: PDE. Smiles: COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1. References: Kunitomo J, et al. J Med Chem. 2014, 57(22):9627-43.
| Keywords: | TAK 063, TAK-063, TAK063 |
| Application: | Targets cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 (PDE10) |
| CAS | 1238697-26-1 |
| MW: | 428.42 D |
From 35.00€
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TAK-063
Item number: Cay22208-5
TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits 14276, Cay-ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063...
| Keywords: | 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-4(1H)-pyridazinone |
| Application: | PDE10A inhibitor |
| CAS | 1238697-26-1 |
| MW: | 428.4 D |
From 117.00€
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