Description: Escin IA (Escin IA,Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 µM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2...

Escin Ia is a triterpenoid saponin that has been found in A. chinensis and has diverse biological activities. It inhibits HIV-1 protease activity in a cell-free assay (IC50 = 35 µM). Escin Ia (2.5, 5, and 10 µM) inhibits the invasion of, and epithelial-to-mesenchymal transition (EMT) in, MDA-MB-231 breast cancer...