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Item number: TGM-T3516-10mg

Description: EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. Target: HDAC. Smiles: CN1C=2C(=CC(N(CCCl)CCCl)=CC2)N=C1CCCCCCC(NO)=O. References: Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the...

Keywords:	Tinostamustine, Minomustine
Application:	Targets histone deacetylase 1/2 [EC:3.5.1.98] (HDAC1_2)
CAS	1236199-60-2
MW:	415.36 D

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EDO-S101

Item number: Cay23328-10

EDO-S101 is a fusion molecule composed of the DNA alkylating agent bendamustine and the histone deacetylase (HDAC) inhibitor SAHA (Cay-10009929) that inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10). It inhibits HDAC activity in rat peripheral blood mononuclear cells (PBMCs) ex vivo by 90%...

Keywords:	5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-1H-benzimidazole-2-heptanamide
Application:	DNA alkylating agent + HDAC inhibitor
CAS	1236199-60-2
MW:	415.4 D

From 61.00€ *

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