Description: rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active. Target: GABA Receptor. Smiles:...

(R,S)-BHFF is a positive allosteric modulator of GABAB receptors that increases the potency of GABA by 15.3-fold in a GTPgamma[35S] binding assay when used at a concentration of 0.3 µM. It is selective for GABAB over a panel of receptors and ion channels at 10 µM, however, it inhibits the cholecystokinin-1 (CCKA)...