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ABT 639
Item number: LKT-A064766.25
ABT-639 is an orally bioavailable, CaV3.2 T-type calcium channel blocker with potential anti-hyperalgesic activity. Upon oral administration, ABT-639 selectively binds to and blocks the CaV3.2 isoform of the low voltage-gated T-type calcium channels located in peripheral sensory neurons. This prevents the influx of...
| Keywords: | ABT639,... |
| Application: | T-type calcium channel blocker |
| CAS | 1235560-28-7 |
| MW: | 455.9 D |
From 252.00€
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ABT-639
Item number: TGM-T3703-100mg
Description: ABT-639 is a potent and selective T-type calcium channel blocker. Target: Calcium Channel. Smiles: [H][C@]12CCCN1CCN(C2)C(=O)c1cc(c(F)cc1Cl)S(=O)(=O)Nc1ccccc1F. References: Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15,89(4):536-44.
| Keywords: | ABT 639 |
| Application: | T-type calcium channel blocker |
| CAS | 1235560-28-7 |
| MW: | 455.91 D |
From 45.00€
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ABT-639
Item number: Cay28742-1
ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Cav3.2 channels with an IC50 value of 2.3 µM and inactivated-state Cav3.1 and Cav3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 µM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over...
| Keywords: | 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-benzenesulfonamide |
| Application: | T-type calcium channel blocker |
| CAS | 1235560-28-7 |
| MW: | 455.9 D |
From 61.00€
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