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AZ20
Item number: TGM-T1958-100mg
Description: AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. Target: mTOR, ATM/ATR. Smiles: C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O. References: Xavier Jacq, et al. Cancer Res 2012,72(8 Suppl):Abstract nr 1823.
| Application: | ATR inhibitor |
| CAS | 1233339-22-4 |
| MW: | 412.51 D |
From 34.00€
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AZ 20
Item number: Cay17589-1
Ataxia telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. AZ 20 is a potent inhibitor of ATR (IC50 = 5 nM). It displays 7.6-fold selectivity over mTOR and minimal activity against a panel of 442 other kinases, including ataxia...
| Keywords: | 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole |
| Application: | ATR inhibitor |
| CAS | 1233339-22-4 |
| MW: | 412.5 D |
From 36.00€
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