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Item number: Cay21560-1

LY2835219 is an orally bioavailable dual inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when...

Keywords:	N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-...
Application:	Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor
CAS	1231929-97-7
MW:	506.6 D

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Abemaciclib

Item number: LKT-A044176.5

CDK inhibitor

Keywords:	LY2835219,...
Application:	CDK inhibitor
CAS	1231929-97-7
MW:	506.61 D

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