2 products were found matching "1228013-30-6"!
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Onatasertib
Item number: TGM-T3351-100mg
Description: Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Onatasertib is a potent mTOR kinase inhibitor (IC50: 16 nM), with...
| Keywords: | CC223, CC 223, CC-223 |
| Application: | Targets serine/threonine-protein kinase mTOR [EC:2.7.11.1] (MTOR, FRAP, TOR) |
| CAS | 1228013-30-6 |
| MW: | 397.47 D |
From 37.00€
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CC-223
Item number: Cay19917-5
CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases. It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems. CC-223 inhibits growth and induces apoptosis in hematologic and...
| Keywords: | 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-pyrazino[2,3-b]pyrazin-2(1H)-one |
| Application: | mTOR inhibitor |
| CAS | 1228013-30-6 |
| MW: | 397.5 D |
From 67.00€
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