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Item number: TGM-T6772-10mg

Description: AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]. Target: Beta-Secretase, BACE. Smiles: NC1=N[C@@](c2cccc(F)c12)(c1cccc(c1)-c1cncnc1)c1ccnc(c1)C(F)F. References: Jeppsson F, et al. J Biol Chem. 2012,...

Keywords:	AZD3839
Application:	BACE1 inhibitor
CAS	1227163-84-9
MW:	431.41 D

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AZD 3839

Item number: Cay28388-1

AZD 3839 is an inhibitor of beta-secretase 1 (BACE1). It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes). It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 µM). AZD 3839 decreases amyloid-beta (Abeta)...

Keywords:	(1S)-1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine
Application:	BACE1 inhibitor
CAS	1227163-84-9
MW:	431.4 D

From 61.00€ *

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