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Item number: TGM-T21738-10mg

Description: PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 16.5 nM, and it inhibits IL-1beta-induced PGE2 synthesis in vitro. Target: Prostaglandin Receptor. Smiles: OC1=C(NS(=O)(=O)c2ccccc12)C(=O)Nc1ccc(cc1)-c1ccc(Cl)c(Cl)c1. References: Gabriel...

CAS	1221971-47-6
MW:	461.32 D

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PF-9184

Item number: Cay18904-1

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2, Cay-17020) into the biologically active PGE2 (Cay-14010). Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. PF-9184 is a potent inhibitor...

Keywords:	N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Application:	mPGES-1 inhibitor
CAS	1221971-47-6
MW:	461.3 D

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