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GSK2033
Item number: TGM-T15427-100mg
Description: GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRalpha or LXRbeta, respectively). Target: Liver X Receptor. Smiles: Cc1cc(C)c(c(C)c1)S(=O)(=O)N(Cc1ccc(o1)C(F)(F)F)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O. References: Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor...
| Application: | LXRalpha / LXRbeta antagonist |
| CAS | 1221277-90-2 |
| MW: | 591.66 D |
From 45.00€
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GSK2033
Item number: Cay25443-1
GSK2033 is an antagonist of liver X receptor alpha (LXRalpha) and LXRbeta (IC50s = 0.1 and 0.398 µM, respectively) that has no agonist activity in an LXR transactivation assay. It inhibits LXR agonist-induced and basal expression of the LXR target genes ATP-binding cassette transporter 1 (ABCA1) and sterol...
| Keywords: | 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfo... |
| Application: | LXRalpha / LXRbeta antagonist |
| CAS | 1221277-90-2 |
| MW: | 591.7 D |
From 44.00€
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