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AVN-492
Item number: TGM-T5179-100mg
Description: AVN-49 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM). Target: 5-HT Receptor. Smiles: CNc1nn2c(C)c(N(C)C)c(C)nc2c1S(=O)(=O)c1ccccc1. References: Ivachtchenko AV, et al. AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation. J Alzheimers Dis. 2017,58(4):1043-1063.
| Keywords: | AVN492 |
| Application: | 5-HT6R antagonist |
| CAS | 1220646-23-0 |
| MW: | 359.45 D |
From 34.00€
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AVN-492
Item number: Cay28079-1
AVN-492 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.09 nM). It selectively inhibits the 5-HT6 receptor over the 5-HT2B receptor (IC50s = 0.19 and 268 nM, respectively, in a radioligand binding assay). AVN-492 inhibits increases in cAMP levels induced by 5-HT in HEK293 cells expressing the...
| Keywords: | N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)-pyrazolo[1,5-a]pyrimidine-2,6-diamine |
| Application: | 5-HT6R antagonist |
| CAS | 1220646-23-0 |
| MW: | 359.4 D |
From 52.00€
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