3 products were found matching "1218778-77-8"!
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LDE225 (phosphate)
Item number: Cay16263-1
LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively). In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in...
| Keywords: | Erismodegib, NVP-LDE225, Sonidegib,... |
| Application: | Smo antagonist |
| CAS | 1218778-77-8 |
| MW: | 681.5 D |
From 43.00€
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NVP-LDE225 Diphosphate
Item number: LKT-N8663.1
Smo inhibitor.
| Keywords: | Erismodegib, Sonidegib |
| Application: | Smo inhibitor |
| CAS | 1218778-77-8 |
| MW: | 681.49 D |
From 69.00€
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Sonidegib, Diphosphate Salt
Item number: LC-S-4699_100mg
Soluble in DMSO. This research compound is the diphosphate salt form of sonidegib. Sonidegib, also known as NPV-LDE-225 and LDE-225, is a potent and selective smoothened (Smo) antagonist. It inhibited the activation of hedgehog signaling, stimulated with 1 nM and 25 nM Ag1.5, with IC50 values of 0.6 and 8 nM,...
| Keywords: | Erismodegib Diphosphate, LDE225 Diphosphate, NPV-LDE225 Diphosphate |
| Application: | Antineoplastic, Smoothened receptor antagonist |
| CAS | 1218778-77-8 |
| MW: | 681.49 D |
From 106.00€
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