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Halofuginone (hydrochloride)
Item number: Cay13370-500
Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga. It has antimalarial and anticoccidial actions. In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-beta signaling and preventing both the differentiation of...
| Keywords: | 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone, monohydrochloride |
| Application: | Antiprotozoal, glutamyl-prolyl-tRNA synthetase (EPRS) inhibitor, Smad3 down-regulator |
| CAS | 1217623-74-9 |
| MW: | 451.1 D |
From 166.00€
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Halofuginone hydrochloride
Item number: TGM-T84443-10mg
Description: Halofuginone hydrobromide (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a K_i value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-beta...
| Keywords: | RU-19110 hydrochloride |
| Application: | Antiprotozoal, glutamyl-prolyl-tRNA synthetase (EPRS) inhibitor, Smad3 down-regulator |
| CAS | 1217623-74-9 |
| MW: | 451.14 D |
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