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GGTI 2133 (trifluoroacetate salt)
Item number: Cay23418-1
GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I, IC50 = 38 nM). It is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). In vitro, it inhibits geranylgeranylation of RAP1A (IC50 = 10 µM) without inhibiting farnesylation of H-Ras (IC50 = >30 µM). It also...
| Keywords: | N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, 2,2,2-trifluoroacetate salt |
| Application: | Geranylgeranyl transferase type I (GGTase I) inhibitor |
| CAS | 1217480-14-2 |
| MW: | 456.5 D |
From 139.00€
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GGTI 2133 TFA
Item number: TGM-T85180-10mg
Description: GGTI 2133, a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I, IC50= 38 nM), exhibits 140-fold selectivity towards GGTase I compared to farnesyltransferase (IC50= 5,400 nM). The compound effectively inhibits the geranylgeranylation of RAP1A (IC50= 10 µM) without affecting the...
| Application: | Geranylgeranyl transferase type I (GGTase I) inhibitor |
| CAS | 1217480-14-2 |
| MW: | 570.569 D |
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