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Item number: TGM-T3654-100mg

Description: APY29 is an allosteric modulator of IRE1alpha, inhibits IRE1alpha autophosphorylation (IC50 = 280 nM) and activates IRE1alpha RNase activity. Target: IRE1. Smiles: C1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1. References: Wang, L., Perera, B., Hari, S., Bhhatarai, B., Backes, B., & Seeliger, M. et al....

Application:	IRE1alpha modulator
CAS	1216665-49-4
MW:	332.36 D

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APY-29

Item number: Cay22913-10

APY-29 is a modulator of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. It binds to the ATP-binding site on IRE1alpha, where it inhibits its autophosphorylation (IC50 = 280 nM) and...

Keywords:	N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Application:	IRE1alpha modulator
CAS	1216665-49-4
MW:	332.4 D

From 139.00€ *

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