4 products were found matching "1211441-98-3"!
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Ribociclib, Free Base
Item number: LC-R-8200_250mg
Soluble in DMSO. Ribociclib, also known as LEE011, is a highly specific CDK4/6 inhibitor. It significantly inhibited proliferation in 12 of 17 human neuroblastoma-derived cell lines with an average IC50 value of 307 nM in the 12 sensitive cell lines. It also caused cell-cycle arrest and cellular senescence that...
| Keywords: | Lee011 |
| Application: | Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434.54 D |
From 113.00€
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LEE011
Item number: Cay17666-10
LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting...
| Keywords: | Ribociclib, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Application: | Cyclin D1/CDK4 & cyclin D3/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434.5 D |
From 54.00€
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LEE011
Item number: SYN-1213-M001
Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...
| Keywords: | LEE-011, Ribociclib |
| Application: | CDK4/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434,5 D |
From 66.00€
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LEE-011
Item number: LKT-L1616.5
CDK4/6 inhibitor.
| Keywords: | LEE011, Ribociclib |
| Application: | CDK4/6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434.54 D |
From 69.00€
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