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Etrasimod
Item number: TGM-TQ0227-100mg
Description: Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells). Target: S1P Receptor, LPL Receptor. Smiles: OC(=O)C[C@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21. References: Buzard DJ, et al. Discovery of APD334:...
| Keywords: | APD334 |
| Application: | Targets sphingosine 1-phosphate receptor 1 (S1PR1, EDG1, CD363) |
| CAS | 1206123-37-6 |
| MW: | 457.48 D |
From 50.00€
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Etrasimod
Item number: Cay21661-1
Etrasimod is an orally bioavailable and potent antagonist of sphingosine-1-phosphate (S1P) receptors with EC50 values of 0.093, 0.44, 0.32, 0.34, and 0.32 nM for human, mouse, rat, dog, and monkey S1P1 receptors. It is selective for S1P1, S1P4, and S1P5 receptors with EC50 values of 6.1, >10,000, >10,000, 147, and...
| Keywords: | APD334, (3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-cyclopent[b]indole-3-acetic acid |
| CAS | 1206123-37-6 |
| MW: | 457.5 D |
From 61.00€
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