Description: 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor. Target: Sirtuin. Smiles: c1[nH]nnc1-c1cccnc1. References: Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015,11(7):1037-51

3-TYP is a sirtuin 3 (SIRT3) inhibitor (IC50 = 38 µM). It is selective for SIRT3 over SIRT1 and SIRT2 at 1 mM. 3-TYP (1 mM) increases acetylation of lysine residues in mitochondrial proteins in HeLa cells. It inhibits the growth of CCRF-CEM, COLO 205, OVCAR-4, OVCAR-8, and SKOV3 cells by greater than 50% when used...