Description: CAY10614 is a TLR4 antagonist. CAY10614 inhibits lipid A-induced activation of TLR4 (IC50=1.675 µM). CAY10614 also improves survival in LPS-induced shock model mice. Target: Others. Smiles: [I-].CCCCCCCCCC CCCCOc1ccc(C[N+](C)(C)C2CCCC2)cc1OCCCCCCCCCCCCCC

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50...

Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g....