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INT-777
INT-777

Item number: TGM-T11662L-100mg

Description: INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 µM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats. Target: GPCR19. Smiles:...
Keywords: S-EMCA
CAS 1199796-29-6
MW: 450.65 D
From 136.00€ *
Review
INT-777
INT-777

Item number: Cay17678-500

TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM). It is active in vivo, stimulating the secretion of glucagon-like peptide 1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge,...
Keywords: HY-15677, 6-EMCA, S-EMCA, (3alpha,5beta,6alpha,7alpha,12alpha,23S)-6-ethyl-3,7,12-trihydroxy-cholane-23-carboxylic acid
Application: TGR5 agonist
CAS 1199796-29-6
MW: 450.7 D
From 163.00€ *
Review