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Item number: TGM-T2639-100mg

Description: LY2811376, an orally available non-peptidic beta-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Abeta secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin....

CAS	1194044-20-6
MW:	320.36 D

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LY2811376

Item number: Cay16712-1

Accumulation of the beta-amyloid (Abeta) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer's disease. Abeta is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE) and gamma-secretase. LY2811376 is a...

Keywords:	(4S)-4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
Application:	BACE1 inhibitor
CAS	1194044-20-6
MW:	320.4 D

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