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Item number: TGM-T21556-100mg

Description: Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzheimer's dementia of the Alzheimer type (SDAT). Target: AChE. Smiles: C(=C\C(O)=O)\C(O)=O.NC1=C2C(=NC=3C1=CC=CC3)CCCC2O. References: Murphy MF, et...

Keywords:	HP 029 maleate, Velnacrine maleate
CAS	118909-22-1
MW:	330.34 D

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Hydroxytacrine (maleate)

Item number: Cay18508-100

Hydroxytacrine is a major active metabolite of tacrine (Cay-70240). It is formed via hydroxylation of tacrine by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Hydroxytacrine inhibits acetylcholinesterase (AChE, IC50 = 4.8 µM). In vivo, hydroxytacrine (33 mg/kg) reverses scopolamine-induced memory impairment...

Keywords:	1-Hydroxytacrine, HP 029, P 83-6029A, Velnacrine, 9-amino-1,2,3,4-tetrahydro-1-acridinol, 2Z-butenedioate
Application:	AChE inhibitor
CAS	118909-22-1
MW:	330.3 D

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