3 products were found matching "1188910-76-0"!
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Agerafenib
Item number: TGM-T2070-100mg
Description: Agerafenib (CEP32496) is a highly potent inhibitor of BRAF. Target: PDGFR, Bcr-Abl, c-RET, Src, Raf, c-Kit. Smiles: COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC. References: Rowbottom MW, et al. J Med Chem, 2012, 55(3), 1082-1105.
| Keywords: | CEP 32496, CEP-32496, CEP32496, RXDX-105 |
| Application: | Raf inhibitor |
| CAS | 1188910-76-0 |
| MW: | 517.46 D |
From 37.00€
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CEP-32496
Item number: LKT-C1660.1
CEP-32496 is a RAF inhibitor for b-Raf(V600E), b-Raf(WT), c-Raf, Abl-1 and CSF-1R.
| Keywords: | N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-Urea |
| Application: | Raf inhibitor |
| CAS | 1188910-76-0 |
| MW: | 517.46 D |
From 344.00€
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CEP-32496
Item number: Cay18776-1
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-RafV600E (Kd = 14 nM in an in vitro binding assay). It blocks...
| Keywords: | N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-urea |
| Application: | Raf inhibitor |
| CAS | 1188910-76-0 |
| MW: | 517.5 D |
From 61.00€
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