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IXA4
Item number: TGM-T9349-100mg
Description: IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function. Target: IRE1. Smiles: CN(CCOc1ccc(C)cc1)C(=O)Cn1cc(NC(=O)CCOc2ccccc2)cn1. References: Grandjean JMD, et al. Pharmacologic...
| Application: | IRE1 activator |
| CAS | 1185329-96-7 |
| MW: | 436.5 D |
From 34.00€
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IXA4
Item number: Cay36788-1
IXA4 is an activator of inositol-requiring enzyme 1 (IRE1). It induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes. In vivo, IXA4 (50 mg/kg) decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity, effects that can be...
| Keywords: | N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-1H-pyrazole-1-acetamide |
| Application: | IRE1 activator |
| CAS | 1185329-96-7 |
| MW: | 436.5 D |
From 39.00€
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