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AMG-337
Item number: TGM-T3209-100mg
Description: AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM). Target: c-Met/HGFR. Smiles: COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(cn34)-c3cnn(C)c3)c(=O)c2c1. References: Hughes PE, et al. Mol Cancer Ther....
| Keywords: | AMG337 |
| Application: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.46 D |
From 36.00€
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AMG 337
Item number: Cay21333-1
AMG 337 is an orally active and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to...
| Keywords: | 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyr... |
| Application: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.5 D |
From 44.00€
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AMG-337
Item number: LKT-A488240.1
| Keywords: | AMG 337, AMG337 |
| Application: | c-Met inhibitor |
| CAS | 1173699-31-4 |
| MW: | 463.47 D |
From 123.00€
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