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INDY
Item number: TGM-T15579-10mg
Description: INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 µM and 0.23 µM and a Ki of 0.18 µM for Dyrk1A ATP pocket, respectively. Target: DYRK. Smiles: CCN1\C(Sc2ccc(O)cc12)=C\C(C)=O. References: Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related...
| Keywords: | 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one |
| Application: | Potent selective ATP-competitive DYRK1A / DYRK1B inhibitor |
| CAS | 1169755-45-6 |
| MW: | 235.3 D |
From 54.00€
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INDY
Item number: AG-CR1-3665-M005
White to off-white solid. Soluble in DMSO (10mg/ml). Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme, Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same...
| Keywords: | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Application: | Potent selective ATP-competitive DYRK1A / DYRK1B inhibitor |
| CAS | 1169755-45-6 |
| MW: | 235,3 D |
88.00€
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INDY
Item number: Cay23895-1
INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A, Ki = 180 nM, IC50 = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 µM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing...
| Keywords: | 1Z-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Application: | DYRK1A inhibitor |
| CAS | 1169755-45-6 |
| MW: | 235.3 D |
From 40.00€
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