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Item number: Cay23414-5

Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha). It is a more potent derivative of salubrinal (Cay-14735) that increases eIF2alpha phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM. It impairs...

Keywords:	(2E)-3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide
Application:	EIF2A dephosphorylation inhibitor
CAS	1164470-53-4
MW:	463.2 D

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Sal003

Item number: TGM-T2417-100mg

Description: Sal003, an effective cell-permeable analog, inhibitis the eIF2alpha phosphatase. Target: Phosphatase, PERK, Apoptosis. Smiles: Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1. References: Robert F, et al. Mol Biol Cell. 2006, 17(11), 4632-4644.

CAS	1164470-53-4
MW:	463.21 D

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