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Item number: TGM-T6857-100mg

Description: HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Target: Apoptosis, Histone Methyltransferase. Smiles: Cl.CCn1c2ccccc2c2cc(CNCc3ccccc3OC)ccc12. References: Tarighat SS, et al. Leukemia. 2016, 30(4):788-799.

Keywords:	HLCL61, HLCL-61 HCL
Application:	PRMT5 inhibitor
CAS	1158279-20-9
MW:	380.91 D

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HLCL-61 (hydrochloride)

Item number: Cay19897-1

HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 µM, respectively). It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an...

Keywords:	9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride
Application:	PRMT5 inhibitor
CAS	1158279-20-9
MW:	380.9 D

From 61.00€ *

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