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Item number: TGM-T5474-100mg

Description: D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit. Target: PDE. Smiles: COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1. References: Zhang C, et al. Comparison of the Pharmacological...

Keywords:	D 159687
Application:	Negative allosteric PDE4D modulator
CAS	1155877-97-6
MW:	366.84 D

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D159687

Item number: Cay38778-10

D159687 is a negative allosteric modulator of phosphodiesterase 4D (PDE4D, IC50 = 28 nM for the human enzyme). It is selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM). D159687 decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253...

Keywords:	N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-urea
Application:	Negative allosteric PDE4D modulator
CAS	1155877-97-6
MW:	366.8 D

From 88.00€ *

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