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Item number: TGM-T6476-100mg

Description: Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and...

Keywords:	UK 68789, UK-68798, Tikosyn
Application:	Targets potassium voltage-gated channel Eag-related subfamily H member 2 (KCNH2, KV11.1)
CAS	115256-11-6
MW:	441.56 D

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Dofetilide

Item number: Cay15045-5

Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...

Keywords:	Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide
Application:	Voltage-gated potassium channel (KCNH2) blocker
CAS	115256-11-6
MW:	441.6 D

From 62.00€ *

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