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CX-5461
Item number: TGM-T2100-100mg
Description: CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA. Target: DNA/RNA Synthesis. Smiles: CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O. References: Drygin D, et al, Cancer Res, 2011, 71(4), 1418-1430.
| CAS | 1138549-36-6 |
| MW: | 513.61 D |
From 37.00€
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CX-5461
Item number: Cay18392-1
CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation. At 50...
| Keywords: | 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridi... |
| Application: | rRNA synthesis inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
From 61.00€
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CX-5461
Item number: SYN-3031-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
| Keywords: | Chantix, Champix |
| Application: | RNA polymerase I inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
From 139.00€
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