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VU0357017 hydrochloride
VU0357017 hydrochloride

Item number: TGM-T3619-100mg

Description: VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM, Pec50: 6.37 ± 0.15). Target: AChR. Smiles: Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C. References: Digby GJ, et al. ACS Chem Neurosci. 2012 Dec...
Keywords: ML071 hydrochloride, VU 0357017 hydrochloride, CID-25010775
Application: M1 muscarinic acetylcholine allosteric agonist
CAS 1135242-13-5
MW: 369.89 D
From 35.00€ *
Review
VU0357017 (hydrochloride)
VU0357017 (hydrochloride)

Item number: Cay11939-1

VU0357017 is an allosteric agonist of M1 muscarinic acetylcholine receptors (mAChRs, Ki = 9.91 µM in CHO cells). In vitro, it is selective for M1 over M2-M5 mAChRs (Kis = 21.4-50 µM in CHO cells). VU0357017 induces concentration-dependent increases in calcium mobilization and activates the ERK signaling pathway with...
Keywords: CID-25010775, 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid, ethyl ester, monohydrochloride
Application: M1 muscarinic acetylcholine allosteric agonist
CAS 1135242-13-5
MW: 369.9 D
From 34.00€ *
Review