Description: Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Target: Antibacterial, Topoisomerase, Antibiotic. Smiles:...

Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 µg/ml) and topoisomerase IV (IC50 = 13.8 µg/ml). It is much less effective against HeLa cell topoisomerase II (IC50 = 265 µg/ml). Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia...