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SAR125844
Item number: TGM-T5467-100mg
Description: SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L). Target: Apoptosis, c-Met/HGFR. Smiles: Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1. References: Egile C, et al. The selective...
| Keywords: | SAR125884 |
| Application: | c-Met inhibitor |
| CAS | 1116743-46-4 |
| MW: | 550.63 D |
From 34.00€
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SAR125844
Item number: Cay37542-1
SAR125844 is an inhibitor of the receptor tyrosine kinase c-Met (IC50 = 4 nM). It is selective for c-Met over tropomyosin-related kinase A (TrkA), TrkB, PDGFRalpha, Axl, and Mer (IC50s = 39, 280, 55, 87, and 105 nM, respectively). SAR125844 inhibits the proliferation of MKN45 gastric cancer cells (IC50 = 7 nM). In...
| Keywords: | N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-urea |
| Application: | c-Met inhibitor |
| CAS | 1116743-46-4 |
| MW: | 550.6 D |
From 49.00€
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