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GSK1838705A
Item number: TGM-T3079-10mg
Description: GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases. Target: IGF-1R, S6 Kinase, ALK, JNK. Smiles: CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12....
| Application: | IGF-1R / IR inhibitor |
| CAS | 1116235-97-2 |
| MW: | 532.57 D |
From 34.00€
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GSK1838705A
Item number: Cay24904-10
GSK1838705A is an inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor (IR, IC50s = 2 and 1.6 nM, respectively). It is selective for IGF-1R and IR over a panel of 47 kinases (IC50s = >1,600 nM), however, it also inhibits anaplastic lymphoma kinase (ALK, IC50 = 0.5 nM). GSK1838705A...
| Keywords: | 2-[[2-[[1-[2-(dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fl... |
| Application: | IGF-1R / IR inhibitor |
| CAS | 1116235-97-2 |
| MW: | 532.6 D |
From 166.00€
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