Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...

Description: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride), a widely used anti-diabetic drug, exhibits potential anti-Y properties by inhibiting the proliferation of various Y cells, including colon and prostate. Target: AMPK, Autophagy, Mitophagy. Smiles: Cl.CN(C)C(=N)NC(N)=N. References: Zhou G,...

AMPK activator. Useful agent for immunometabolism research. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation. Mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive...

Metformin Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Metformin is an antihyperglycemic agent of the biguanide class, used for the management of type II diabetes and is currently prescribed to at least 120 million people worldwide. It is an AMPK activator and a mitochondrial...

AMPK activator.