Description: JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 µM for inhibition of MAGL and FAAH in mouse brain membranes respectively. Target: Lipase. Smiles: OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1. References: Long JZ, et al. Nat Chem Biol, 2009, 5(1), 37-44.

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to...