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GSK2126458
Item number: Cay17377-1
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110alpha, beta, delta, and gamma, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110alpha. GSK2126458 is orally...
| Keywords: | GSK458, Omipalisib, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-benzenesulfonamide |
| Application: | PI3K inhibitor, mTOR inhibitor |
| CAS | 1086062-66-9 |
| MW: | 505.5 D |
From 66.00€
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GSK2126458
Item number: LKT-G7342.1
GSK2126458 is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer...
| Keywords: | GSK-2126458, 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide |
| Application: | PI3K inhibitor |
| CAS | 1086062-66-9 |
| MW: | 505.5 D |
From 90.00€
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GSK-2126458
Item number: SYN-1126-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymes and MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range...
| Keywords: | HYR-582 |
| Application: | PI3K / mTOR inhibitor |
| CAS | 1086062-66-9 |
| MW: | 505,5 D |
From 191.00€
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