Description: Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. Target: AMPK, Nrf2, HIV Protease. Smiles:...

Ganodermanondiol is a triterpenoid that has been found in G. lucidum and has diverse biological activities. It inhibits the proliferation of Meth A sarcoma and LLC1 lung carcinoma cells (IC50s = 3.4 and 12.5 µg/ml, respectively). Ganodermanondiol (20 µM) reduces the viability of RAW 264.7 macrophages. It inhibits...