Description: N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis. Target: ADC Linker. Smiles: [Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O. References: Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug...

N-Hydroxysulfosuccinimide (sulfo-NHS) is a modifying reagent that, in the presence of a cross-linking reagent like carbodiimide or EDAC, converts carboxyl groups to amine-reactive sulfo-NHS esters. The cross-linker converts the carboxylic acid to an unstable o-acylisourea intermediate, which then reacts with the...