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Item number: TGM-T1943-100mg

Description: ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. Target: ALK, TGF-beta/Smad. Smiles: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12. References: Engers DW, et al. Bioorg Med Chem Lett. 2013, 23(11), 3248-3252.

Keywords:	LDN 193719
Application:	ALK1 / ALK2 inhibitor
CAS	1062368-49-3
MW:	352.39 D

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ML-347

Item number: Cay17640-1

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. ML-347 is a 5-quinoline compound...

Keywords:	LDN193719, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Application:	ALK1 / ALK2 inhibitor
CAS	1062368-49-3
MW:	352.4 D

From 52.00€ *

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