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LDN-193189

Item number: Cay11802-1

Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...

Keywords:	4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Application:	BMP type I receptor inhibitor
CAS	1062368-24-4
MW:	406.5 D

From 47.00€ *

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LDN193189

Item number: TGM-T1935-100mg

Description: LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). Target: ALK, TGF-beta/Smad. Smiles: C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12. References: Yu PB, et al. BMP type I...

Keywords:	DM-3189, LDN 193189, LDN-193189
Application:	BMP type I receptor inhibitor
CAS	1062368-24-4
MW:	406.48 D

From 42.00€ *

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