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Momelotinib
Item number: TGM-T1849-100mg
Description: Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the...
| Keywords: | CYT387, LM-1149, CYT11387 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1056634-68-4 |
| MW: | 414.46 D |
From 33.00€
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CYT387
Item number: Cay16246-1
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines....
| Keywords: | Momelotinib, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414.5 D |
From 111.00€
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Momelotinib
Item number: SYN-1035-M005
Soluble in DMSO. CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM)...
| Keywords: | CYT387, Momelotinib |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414,5 D |
From 123.00€
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CYT-387
Item number: LKT-C9876.1
JAK2 inhibitor.
| Keywords: | CYT387, CYT11387, Momelotinib |
| Application: | Janus kinase 1 (JAK1) inhibitor, janus kinase 2 (JAK2) inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414.46 D |
From 142.00€
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