Description: ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction. Target: ERK. Smiles: Cl.O=C1SC(=CC2=CC=C(OCC)C=C2)C(=O)N1CCN. References: Chad N Hancock, et al. Identification of novel extracellular signal-regulated kinase...

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect...