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Item number: TGM-T6181-100mg

Description: UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 µM). It is ~27-fold selective against PARP1. Target: PARP. Smiles: O=C(COc1cccc2c1cc[nH]c2=O)c1ccccc1. References: Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.

Application:	PARP inhibitor
CAS	1048371-03-4
MW:	279.29 D

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UPF-1069

Item number: Cay17760-1

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. UPF-1069 is a PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively). In rat models of...

Keywords:	GKT237841, 5-(2-oxo-2-phenylethoxy)-1(2H)-isoquinolinone
Application:	PARP inhibitor
CAS	1048371-03-4
MW:	279.3 D

From 43.00€ *

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