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Item number: TGM-T5094-100mg

Description: IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 µM) and JNK-2 (IC50>10 µM). Target: JNK, IRAK. Smiles: C1CC(CCN1)Nc1cccc(n1)-c1cnc2ccccn12. References: Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of...

Application:	IRAK inhibitor
CAS	1042224-63-4
MW:	293.37 D

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IRAK Inhibitor 1

Item number: Cay36637-1

IRAK inhibitor 1 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 35 nM). It is selective for IRAK4 over JNK1 and JNK2 at 10 µM. IRAK inhibitor 1 (1 µM) prevents increases in TNF-alpha and IL-12p40 levels in THP-1 cells infected with M. bovis.Formal Name:...

Keywords:	IRAK4-IN-1, 6-imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
Application:	IRAK4 inhibitor
CAS	1042224-63-4
MW:	293.4 D

From 82.00€ *

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